| Polymorphisms of IL-4, IL-4Rα, and AICDA Genes in Adult Allergic Asthma |
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| 引用本文： | 崔天盆,王琳,吴健民,胡丽华,谢俊刚.Polymorphisms of IL-4, IL-4Rα, and AICDA Genes in Adult Allergic Asthma[J].华中科技大学学报(医学英德文版),2003,23(2). |
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| 作者姓名： | 崔天盆 王琳 吴健民 胡丽华 谢俊刚 |
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| 作者单位： | Immunology Laboratory，Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Life Science College of Wahan University，Wuhan 430071，Immunology Laboratory，Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Immunology Laboratory，Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Department of Respiratory Diseases，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030 |
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| 摘 要： | The relationship between 3 polymorphisms sites interleulin-4 (IL-4), IL-4 receptor (IL-4R)α chain and activation-induced cytidine deaminase (AICDA)] and adult allergic asthma in Chinawas studied. By using case-control method, DNA and clinical data were obtained from allergic asth-matic patients and compared with those in the control subjects. The subjects were genotyped for theIL-4 C-589T promoter polymorphism, the IL-4R α chain Q576R and the AICDA C8408T by poly-merase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The resultsshowed that the IL-4 C-589T was not associated with adult allergic asthma in China. However, theIL-4R α chain 576R/R and AICDA 8408T/T frequency was significantly increased in allergic asthmagroup as compared with that in the control group odd ratio (OR) =3.797 and 9.127, respectively;P<0.01)] and was correlated with the increased plasma total IgE. These data suggested that theIL-4R α chain 576R/R and AICDA 8408T/T genotypes confer genetic suscept
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Polymorphisms of IL-4, IL-4Rα, and AICDA Genes in Adult Allergic Asthma |
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| GUI Tianpen WANG Lin WU Jianmin HU Lihua XIE Jungang Immunology Laboratory,Xiehe Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan
Life Science College of Wahan University,Wuhan.Polymorphisms of IL-4, IL-4Rα, and AICDA Genes in Adult Allergic Asthma[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2003,23(2). |
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| Authors: | GUI Tianpen WANG Lin WU Jianmin HU Lihua XIE Jungang Immunology Laboratory Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan
Life Science College of Wahan University Wuhan |
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| Institution: | GUI Tianpen WANG Lin WU Jianmin HU Lihua XIE Jungang Immunology Laboratory,Xiehe Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022
Life Science College of Wahan University,Wuhan 430071
Department of Respiratory Diseases,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | Summary: The relationship between 3 polymorphisms sites interleulin-4 (IL-4), IL-4 receptor (IL-4R) α chain and activation-induced cytidine deaminase (AICDA)] and adult allergic asthma in Chinawas studied. By using case-control method, DNA and clinical data were obtained from allergic asth-matic patients and compared with those in the control subjects. The subjects were genotyped for theIL-4 C-589T promoter polymorphism, the IL-4R α chain Q576R and the AICDA C8408T by poly-merase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The resultsshowed that the IL-4 C-589T was not associated with adult allergic asthma in China. However, theIL-4R α chain 576R/R and AICDA 8408T/T frequency was significantly increased in allergic asthmagroup as compared with that in the control group odd ratio (OR)= 3. 797 and 9. 127, respectively;P＜0.01)] and was correlated with the increased plasma total IgE. These data suggested that theIL-4R α chain 576R/R and AICDA 8408T/T genotypes confer genetic susceptibility to adult allergicasthma in China. |
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| Keywords: | allergic asthma interleukin-4 interleukin-4 receptor activation-induced cytidine deaminase |
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