Detection of Serum Hyaluronic Acid and Laminin in Patients with Bladder Tumors

Hyaluronicacid (HA) and laminin (LN) arethemajor components of extracellular matrix. They canregulate adhesion,diffusion,migration and prolifera-tion of cell.It is especially affirmed that LN has aclose relationship with tumor biological property1] .Many scholarshave made an extensiveresearch aboutthem with breastcancer,colon cancerand so on,butrarely with urologic tumors. Our study was to ex-plore the relationship between the levels of HA andLN in serum and the clinical observation in pa…

Detection of serum hyaluronic acid and laminin in patients with bladder tumors

In order to investigate the changes of serum hyaluronic acid (HA) and laminin (LN) le-vels and their clinical implication in the patients with bladder tumors, the serum HA and LN levels in 34 patients with bladder tumor and 30 cases of control group were detected by radioimmunoassay before and after operation. The results showed that the serum HA and LN levels in the patients with bladder tumors were significantly higher than those in control group (P<0.01) before operation, and decreased significantly after operation (P<0.05). The serum levels of HA and LN in infiltration tumors were higher than those in superficial tumors (P<0.05). The serum HA and LN levels in patients with lymph node metastasis were higher than those without lymph node metastasis (P<0.01). The investigation revealed that HA and LN might be involved in the malignant biology behavior of bladder tumors and could be used as important markers of assistant diagnosis and condition monitoring.