| Observation on In Situ Hybridization and Immunocytochemistry of Matrix Metalloproteinases in Rat Pancreas |
| |
| 作者姓名： | 唐立华 刘胜洪 王芳 刘子龙 许耘 王小丽 李肇春 |
| |
| 作者单位： | Department of Histology and Embryology，Department of Histology and Embryology，Department of Reproductive Medicine Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030 |
| |
| 摘 要： | Matrixmetalloproteinases (MMP) ,asanimpor tantenzyme ,mayplayacriticalroleinthedegenera tionofextracellularmatrix .Itcanbeclassifiedintoseveraltypes .Amongthem ,matrixmetallo pro teinases 1(MMP 1) ,whichcandissolvecollagenfiberinintercellularmatrixareinvolvedinthediffer entiation ,remodelingandregenerationoftissuesandorgans1,2 ] .AlthoughtheexpressionofMMPhasbeendetectedinpancreas ,thecellularlocationoftheenzymeinpancreasremainselusive .Inthisexperi ment,thelocalizationanddistributionofM…
|
Observation on In Situ Hybridization and Immunocytochemistry of Matrix Metalloproteinases in Rat Pancreas |
| |
| TANG Lihua ,LIU Shenghong ,WANG Fang,LIU Zilong ,XU Yun,WANG Xiaoli,LI Zhaochun.Observation on In Situ Hybridization and Immunocytochemistry of Matrix Metalloproteinases in Rat Pancreas[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2003,23(4). |
| |
| Authors: | TANG Lihua LIU Shenghong WANG Fang LIU Zilong XU Yun WANG Xiaoli LI Zhaochun |
| |
| Institution: | 1. Department of Histology and Embryology, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030
2. Department of Reproductive Medicine, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030 |
| |
| Abstract: | In situ hybridization and immunocytochemical techniques were employed to examine the expression of matrix metalloproteinases 1 (MMP 1) and to identify the pattern of its distribution in rat pancreas. The results indicated that the signal of MMP 1 mRNA and MMP 1 positive immunoreaction were detected in some fiberoblasts around interlobular ducts and exocrine cell in margin acinus of some lobules, but the signal of MMP 1 mRNA and MMP 1 positive immunoreaction could not be detected in most of other acinus and islets of pancreas. It is concluded that the expression of MMP 1 in above cells of rat might play an important role in acinar proliferation and differentiation of rat pancreatic tissues. |
| |
| Keywords: | matrix metalloproteinases 1 in situ hybridization pancreas rat |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
