| Experimental Study of Vascular Endothelial Growth Factor Gene Therapy for Avascular Necrosis of the Femoral Head |
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| 作者姓名： | 杨操 杨述华 杜靖远 李进 许伟华 熊宇芳 |
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| 作者单位： | Department of Orthopedics，Department of Orthopedics，Department of Orthopedics，Department of Orthopedics，Department of Orthopedics，Department of Biochemistry Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030 |
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| 基金项目： | ThisprojectwassupportedbyagrantfromNationalNaturalSciencesFoundationofChina (No 30 170 94 5 ) |
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| 摘 要： | Avascularnecrosisofthefemoralheadisanin creasingcauseofmusculoskeletalmorbidityinyoungandmiddleagedpersons It’sadebilitatingdiseasethatusuallyleadstodestructionofthehipjoint To taljointreplacementiscommonlyusedtotreatdis ablingsecondaryosteoarthrosis Althoughthemostrecentimprovementsintotalhipreplacementmayde creasethefailure ,thepatientsareusuallyyoungandthecurrenthipprothesiswouldn’tfunctionwellfortheremaininglifeexpectancyforthesepatients Forthisreason ,it’snecessarytodelayoreliminatethe…
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| 收稿时间： | 4 September 2002 |
Experimental study of vascular endothelial growth factor gene therapy for avascular necrosis of the femoral head |
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| Yang?Cao,Yang?Shuhua,Du?Jingyuan,Li?Jin,Xu?Weihua,Xiong?Yufang.Experimental Study of Vascular Endothelial Growth Factor Gene Therapy for Avascular Necrosis of the Femoral Head[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2003,23(3):297-299. |
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| Authors: | Yang Cao Yang Shuhua Du Jingyuan Li Jin Xu Weihua Xiong Yufang |
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| Institution: | 1. Department of Orthopedics, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technolog y,Wuhan 430022
2. Department of Biochemistry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 |
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| Abstract: | To explore a new method for the therapy of the avascular necrosis of the femoral head, the recombinant plasmid pCD-hVEGF 165 was mixed with collagen and was implanted in the necrotic femoral head The expression of vascular endothelial growth factor (VEGF) was detected by RNA dot hybridization and immunohistochemical method The repair of the femoral head was observed by histological method The results showed that the expression of VEGF was detectable in the femoral head treated with VEGF gene Angiogenesis in these femoral heads was more abundant than the control Bone repairing was augmented in the femoral head treated with VEGF gene The results suggest that angiogenesis in bone tissue could be augmented by gene transfection of VEGF and bone repairing would be accelerated accordingly |
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| Keywords: | vascular endothelial growth factor gene therapy avascular necrosis of the femoral head |
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