| The Role of Endogenous Carbon Monoxide in the Hypoxic Vascular Remodeling of Rat Model of Hypoxic Pulmonary Hypertension |
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| 作者姓名： | 甄国华 张珍祥 徐永健 |
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| 作者单位： | Department of Pulmonary Medicine，Department of Pulmonary Medicine，Department of Pulmonary Medicine Tongji Hospital，Tongji Medical College，Huazhong University of Science & Technology，Wuhan，430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science & Technology，Wuhan，430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science & Technology，Wuhan，430030 |
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| 摘 要： | Itisknownthatpulmonaryvascularremodelingisthekeymechanisminthedevelopmentofchronicpulmonaryhypertension ,whichischaracterizedbythethicknessofthemediacausedbytheproliferationofsmoothmusclecellsandthemusculizationoftheintra acinarpulmonaryarteries1] .Hemeoxygenase(HO)catalyzesthebreakdownofhemeintocarbonmonoxide (CO ) ,biliverdinandironinmammals .TherearetwoisoformsofHO ,HO 1andHO 2 2 ] .HO 1istheinducibleisoformwhichcanbeinducedbyhyoxia ,shockandotherstresssettingsand pro duceCO .Itwasr…
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| 收稿时间： | 19 April 2002 |
The role of endogenous carbon monoxide in the hypoxic vascular remodeling of rat model of hypoxic pulmonary hypertension |
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| Zhen?Guohua,Zhang?Zhenxiang,Xu?Yongjian.The Role of Endogenous Carbon Monoxide in the Hypoxic Vascular Remodeling of Rat Model of Hypoxic Pulmonary Hypertension[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2003,23(4):356-358. |
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| Authors: | Zhen Guohua Zhang Zhenxiang Xu Yongjian |
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| Institution: | Department of Pulmonary Medicine, Tongji Hospital, Tongji Medical College,Huazhong University of Science & Technology, Wuhan , 430030 |
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| Abstract: | |
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| Keywords: | heme oxygenase hypoxia pulmonary hypertension pulmonary vascular remodeling |
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