| Influence of Electroacupuncture on the mRNA of Heat Shock Protein 70 and 90 in Brain after Cerebral Ischemia/Reperfusion of Rats |
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| 引用本文： | 孙宁,施静,陈丽玲,刘晓春,关新民. Influence of Electroacupuncture on the mRNA of Heat Shock Protein 70 and 90 in Brain after Cerebral Ischemia/Reperfusion of Rats[J]. 华中科技大学学报(医学英德文版), 2003, 23(2): 112-115. DOI: 10.1007/BF02859930 |
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| 作者姓名： | 孙宁 施静 陈丽玲 刘晓春 关新民 |
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| 作者单位： | Department of Neurobiology，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Department of Neurobiology，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Department of Neurobiology，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Department of Neurobiology，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Department of Neurobiology，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030 |
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| 摘 要： | To explore the anti-apoptotic role of electroacupuncture (EA) and its molecular mecha-nisms after cerebral ischemia/reperfusion (IR) of rats, by using animal model of middle cerebralartery occlusion (MCAO), the changes of the cleavage of PARP were observed by Western blot andthe mRNA of heat shock protein (Hsp) 70 and Hsp90β detected by competitive RT-PCR after cere-bral IR and EA treatment. The results were as follows: (1) The cleavage of PARP was increased inischemic hippocampus, and EA treatment could attenuate the level of the cleavage remarkably; (2)The mRNA expression of Hsp70 was increased in the ischemic cortex and hippocampus and was fur-ther increased after EA treatment; (3) The mRNA expression of Hsp90β was decreased in ischemiccortex and hippocampus and the decrease was relatively slight after EA treatment. The above resultsdemonstrated EA treatment could protect neurons from apoptosis after cerebral IR. One of the molec-ular mechanisms was the promotion of the inducible expression of Hsp7
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| 收稿时间： | 2003-02-28 |
Influence of electroacupuncture on the mRNA of heat shock protein 70 and 90 in brain after cerebral ischemia/reperfusion of rats |
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| Ning,Sun,Jing,Shi,Liling,Chen,Xiaochun,Liu,Xinmin,Guan. Influence of electroacupuncture on the mRNA of heat shock protein 70 and 90 in brain after cerebral ischemia/reperfusion of rats[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2003, 23(2): 112-115. DOI: 10.1007/BF02859930 |
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| Authors: | Ning Sun Jing Shi Liling Chen Xiaochun Liu Xinmin Guan |
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| Affiliation: | Department of Neurobiology,Tongji Medical College, Huazhong University of Science and Technoloy,Wuhan 430030 |
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| Abstract: | Current Medical Science - To explore the anti-apoptotic role of electroacupuncture (EA) and its molecular mechanisms after cerebral ischemia/reperfusion (IR) of rats, by using animal model of... |
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| Keywords: | cerebral ischemia/reperfusion electroacupuncture apoptosis PARP Hsp70 Hsp90 |
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