神经外科手术前盐酸戊乙奎醚黏膜给药临床研究

目的：在神经外科手术中观察对比不同剂量盐酸戊乙奎醚麻醉前黏膜给药对肌松、镇静、血流动力学及术中和术后腺体分泌的影响。方法：选择45例择期神经外科手术患者（ASAⅠ~Ⅱ级），采用随机分组的方式，将其分为三组，C组通过口鼻腔黏膜于麻醉前30 min注射用水1 mL，P1组给予盐酸戊乙奎醚0.5 mg，P2组给予盐酸戊乙奎醚1 mg。采用阻抗法通过在双盲的条件下观察给药前、后不同时段血流动力学改变，从而量化判断每组患者的口干程度，同时注重观察不同手术时段其对腺体分泌的影响。结果：盐酸戊乙奎醚在麻醉前黏膜给予对抑制腺体分泌影响明显，对心搏量、心输出量、心率无明显影响（P〉0.05），盐酸戊乙奎醚可延长肌松剂的维持时间。结论：盐酸戊乙奎醚与抑制腺体分泌在麻醉前黏膜给予条件下呈剂量相关性，其对心血管无明显兴奋作用，可能延长肌松药的作用时间。

A Clinical Study of Penehyclidine Hydrochloride Administrated Mucosally as Premedication for Neurosurgical Patients

Objective：To observe the effects of Penehyclidine Hydrochloride giving from glue in premedicate in the neurosurgery surgical operation.Method：In a double-blind,randomized study,45 adult patients scheduled to neurosurgery surgical operation were assigned to three groups.P1 group（enehyclidine hydrochloride 0.5 mg plus injective water 0.5 mg）,P2 group（enehyclidine hydrochloride 1 mg）,C group（injective water 1 mg）. The heart rate,invasive artery blood pressure,SV,CI,and gland secreting,muscle relaxation were recorded.Result：Penehyclidine hydrochloride giving from glue as premeditation could effect the gland secretion（P〈0.01）. Penehyclidine hydrochloride had significant stability on HR,SV and CI.Penehyclidine hydrochloride could prolong the time which T4/T1 recovered 25%.Conclusion：Penehyclidine hydrochloride,a new anticholinergic drug,has a significant stability on HR,has not a significant effection on SV,CI.Penehyclidine hydrochloride can decrease the muscle relaxant.