| 考来烯胺治疗原发性高脂血症67例 |
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| 引用本文： | 陆德澄,汤永祥,戴玉瑛,雍晓勤,陈志梅.考来烯胺治疗原发性高脂血症67例[J].中国新药与临床杂志,1994(6). |
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| 作者姓名： | 陆德澄 汤永祥 戴玉瑛 雍晓勤 陈志梅 |
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| 作者单位： | 镇江医学院附属医院，南京石山头制药厂，镇江焦化厂卫生所 |
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| 摘 要： | 原发性高脂血症６７例（男性４６例，女性２１例；年龄５５±ｓ１１ａ）用考来烯胺１６ｇ／ｄ，分３次服，共治疗８ｗｋ。另相同患者３５例（男性２２例，女性１３例；年龄５１±１１ａ）用非诺贝特１００ｍｇ，Ｐｏ，ｔｉｄ，共８ｗｋ作为对照。结果：考来烯胺组ＴＣ，ＬＤＬ－ｃｈ，ＴＣ／ＨＤＬ－ｃｈ，ＡｐｏＢ，ＬＰ（ａ）分别下降３３％，４６％，５２％，３０％，３６％；ＨＤＬ－ｃｈ，ＡｐｏＡ／ＡｐｏＢ分别上升３８％，８６％。组间对照均优于对照组（Ｐ＜０．０１）。不良反应亦较轻微。
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| 关 键 词： | 考来烯胺 非诺贝特 胆甾醇 高密度脂蛋白类 低密度脂蛋白类 |
Colestyramine in treatment of primary hyperlipemia in 67 patients |
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| LU De-Cheng,TANG Yong-Xiang,DAI Yu-Ying,YONG Xiao-Qin,CHEN zhi-Mei.Colestyramine in treatment of primary hyperlipemia in 67 patients[J].Chinese Journal of New Drugs and Clinical Remedies,1994(6). |
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| Authors: | LU De-Cheng TANG Yong-Xiang DAI Yu-Ying YONG Xiao-Qin CHEN zhi-Mei |
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| Abstract: | Sixty-seven patients(M 46, F21; age 55±s 11 a) with primary hyperlipemia were treated with colestyramine 16 g /d,po, in 3 divided doses for 8 wk.Other similar 35 patients(M 22, F 13; age 51±11 a) received fenofibrate 100 mg, po,tid for 8 wk, served as control.Results showed decrease of serum TC, LDL-ch,TC/HDL-ch,Apo B, LP(a) by 33%,46%, 52%, 30%, 36%, respectively, while serum HDL-ch,Apo A/Apo B increased by 38%, 86%,respectively(P<0.01).Adverse reactions of two groups were all mild. |
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| Keywords: | cholestyramine procetofen cholesterol HDL lipoproteins LDL lipoproteins |
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