Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels |
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| Authors: | Hink Ulrich Daiber Andreas Kayhan Nalan Trischler Jordis Kraatz Catharina Oelze Matthias Mollnau Hanke Wenzel Philip Vahl Christian F Ho Kwok Ki Weiner Henry Munzel Thomas |
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| Affiliation: | II Medizinische Klinik für Kardiologie und Angiologie, Johannes Gutenberg University, Mainz, Germany. |
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| Abstract: | |
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| Keywords: | ALDH-2, mitochondrial aldehyde dehydrogenase DTT, dithiothreitol EC50, half-maximal concentration eNOS, endothelial nitric oxide synthase GTN, glycerol trinitrate, nitroglycerin ROS, reactive oxygen species |
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