Invalidisierende Kalziphylaxie (Calcific uraemic arteriolopathy)

We present the case of a 45-year-old man with diabetes mellitus type 1 and end-stage renal failure who was treated with haemodialysis for 2 years and received a renal transplant at the age of 35. Due to clinical progression with recurrent acral necrosis, the diagnosis of calciphylaxis was made. Over the course of time, many amputations on both hands and legs were necessary. The pathogenesis, clinical features, diagnosis, and treatment of calciphylaxis are discussed.