Direct thrombin inhibition in interventional cardiology. The ACUITY trial |
| |
Authors: | Heinze H Darius H |
| |
Affiliation: | Vivantes Klinikum Neuk?lln, Kardiologie und konservative Intensivmedizin, Rudower Strasse 48, 12351 Berlin. |
| |
Abstract: | The direct thrombin inhibitor bivalirudin was tested in the ACUITY Trial 13 819 patients with acute non-ST-segment elevation coronary syndrome in a prospective and randomized design. Three therapeutic regimens were compared in the context of an early invasive strategy: heparin plus glycoprotein IIb/IIIa inhibitor (GPI), bivalirudin plus GPI, or bivalirudin alone. Concerning the rate of ischaemic events bivalirudin alone was comparable to heparin plus GPI at a significantly lower rate of bleeding complications. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|