冠心病患者氧化型低密度脂蛋白自身抗体的检测及临床意义

目的探讨血清氧化型低密度脂蛋白自身抗体(anti-oxLDL)与冠心病病变程度的关系.方法 检测2006年1月至2010年1月在本科诊治的60例冠心病患者血清anti-oxLDL水平,比较在不同类型冠心病之间的差异.结果 正常组(冠状动脉无狭窄)血清anti-oxLDL水平低,SAP组、UAP组和AMI组的血清anti-oxLDL水平显著高于正常组(P<0.05),且随着冠状动脉狭窄程度(Gensini积分)增加血清anti-oxLDL水平亦增加(P<0.05);Logistic回归分析表明,血清anti-oxLDL水平与冠心病呈正相关.结论 血清anti-oxLDL与冠心病病变程度正相关,是冠心病的危险因素.

The measurement of autoantibodies of oxidized low density lipoprotein and its clinical value in patients with coronafy heart disease

Objective To explore the value of the measurement of autoantibodies of oxidized low density lipoprotein （anti - oxLDL） and the seriousness of coronary heart disease（CHD）. Methods The serum level of anti - oxLDL in 60 cases of CHD from Jan, 2006 to Jan, 2010 were measured and compared, the difference between different type of CHD was compared. Results The serum level of serum anti - oxLDL in normal group （ no restrictions in coronary artery ） was low, the anti - oxLDL level in SAP group, UAP and AMI group were higher than the normal group（ P 〈 0. 05 ）, the level rose as the degree of coronary stricture （ Gensini score） increased（ P 〈 0.05 ） ; the Logistic regression analysis. Conclusions The serum level of anti - oxLDL were positively correlated to CHD and is a risk factor.