前列腺癌患者全身核素骨显像与病理分级及PSA关系分析

目的 探讨单光子发射型计算机断层(ECT)全身核素骨显像诊断前列腺癌骨转移的价值,以及前列腺癌发生骨转移的规律及与病理分级、PSA(前列腺癌糖蛋白抗原)之间的关系.方法 回顾性分析142例前列腺癌患者资料.术前均测定血清PSA水平及全身骨ECT检查,术后病理分级.结果 142例前列腺癌患者,全身骨显像中107例有骨转移(占75 35%),骨转移好发部位为脊柱(87例,占30 96%)和骨盆(84例,占29 89%).PSA越高骨转移发生率越大,肿瘤分化程度越低骨转移发生率亦相应增加,差异均有统计学意义(P<0 01).结论 全身骨扫描诊断前列腺癌骨转移有重要价值,前列腺癌血清PSA值、病理分级与前列腺癌骨转移发生率相关.

The relationships among emission computed tomography (ECT) bone imaging, pathological findings and serum PSA in patients with prostate cancer

Objective To study the valus of emission computed tomography（ECT） bone imaging, and the relationships among emission computed tomography（ECT） bone imaging, pathological findings and serum PSA in patients with prostate cancer, also to explore the pattern of osseous metastasis. Methods 142 cases of prostate carcinoma were reviewed and the correlation between ECT,PSA and bone metastasis was analyzed. Results The incidence of bone metastasis of prostate cancer was 75.35%. The predilection site of bone metastasis was vertebral column （30. 96% ） and pelvis （29.89%）. The value of PSA between bone metastasis group and non -bone metastasis group had significant difference （P 〈 0.01 ） ;the pathological grade also had significant difference. Conclusions ECT is a high value in diagnosis of bone metastasis of prostate cancer. There is direct correlation between Gleason score,PSA and bone metastasis.