重症急性胰腺炎预后的早期相关因素分析

目的探讨重症急性胰腺炎(severe acute pancreatitis,SAP)患者入院24 h内与预后的相关因素.方法 对193例SAP患者临床资料作回顾性分析.按预后分为死亡组和存活组,先以单因素分析筛选有统计学意义的影响因素,再通过Logistic回归分析筛选与预后有关的影响因素.结果 SAP死亡组患者年龄、血钙、阴离子间隙、血浆总蛋白、血清白蛋白、肌酐、尿素氮与存活组患者比较差异有统计学意义(P<0.05),SAP死亡组患者性别、病因、红细胞比积、白细胞计数、血小板计数、氧分压、谷草转氨酶、谷丙转氨酶、乳酸脱氢酶与存活组患者比较差异无统计学意义(P>0.05).Logistic回归分析显示早期血肌酐、血清总蛋白浓度与SAP预后存在相关性(P<0.05).结论 入院24h内的血肌酐、血清总蛋白浓度是影响SAP预后的早期因素.

Analysis of prognosis-related factors for severe acute pancreatitis

Objective To investigate the prognosis - related factors for severe acute pancreatitis within 24 hours after admission. Methods A total of 193 consecutive patients of severe acute pancreatitis were studied retrospectively. According to the prognosis, they were divided into the death group and the survival group. Seek for the prognosis - related factors by means of univariate analysis, and then by logistic regression analysis. Results There were of significant differences in average age, anion gap, total plasma protein, serum albumin, creatinine, usea nitrogen of the two groups （ P 〈 0. 05 ） , whereas there were not of significant differences in gender, etiology, hematocrit, white blood cell count, platclet count, oxygen partial pressure, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactate dehydrogenase of the two groups（P 〉 0. 05）. Creatinine and total plasma protein were associated with the prognosis of severe acute pancreatitis by logistic regression analysis（ P 〈 0. 05 ）. Conclusion The concentration of reatinine and total plasma protein within 24 hours after admission were the prognosis - related factors for severe acute pancreatitis.