夫西地酸和万古霉素对耐甲氧西林金黄色葡萄球菌体外抗菌活性的研究

目的了解耐甲氧西林金黄色葡萄球菌对夫西地酸和万古霉素的耐药率动态变化。方法应用回顾性调查方法，对本院从2004年1月至2008年12月间临床样本分离的耐甲氧西林金黄色葡萄球菌夫西地酸和万古霉素药敏试验进行统计分析。结果所分离出的耐甲氧西林金黄色葡萄球菌772株，占金黄色葡萄球菌的78．1％，耐甲氧西林金黄色葡萄球菌对万古霉素高度敏感，夫西地酸耐药率有整体上升趋势。结论本地区耐甲氧西林金黄色葡萄球菌检出率维持在较高水平，夫西地酸和万古霉素是治疗MRSA感染的理想药物，但要注意耐夫西地酸菌株的爆发流行和耐万古霉素菌株的出现。

In vitro antibacterial activity of fusidic acid and vancomycin against methicillin-resistaut staphylococcus aureus

Objective To study the resistance and dynamic changes of methicillin-resistant staphylococcus aureus to fusidic acid and vancomycin. Methods The experimental data of antimicrobial susceptibility of fusidic acid and vancomycin of the methicillin-resistant staphylococcus aureus during January 2004 to December 2008 were retrospective statistical analyzed. Results The isolated methicillin-resistant staphylococcus aureus were 772 strains, which was about 78.1% of the staphylococcus aureus. The methicillin-resistant staphylococcus aureus were highly sensitive to vancomycin. The drug resistance ratio of fusidic acid was at a rising trend. Conclusion In this region methicillin-resistant staphylococcus aureus detection rate remained at a relatively high level. Fusidic acid and vancomycin are good medicines to cure the infection caused by methicillin-resistant staphylococcus aureus. But we should caution the occurrence of resistant fusidic acid and vancomycin strains.