| 乳酸-羟基乙酸共聚物(PLGA)微球控释系统的突释 |
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| 引用本文： | 叶美娣, 郑彩虹. 乳酸-羟基乙酸共聚物(PLGA)微球控释系统的突释[J]. 中国现代应用药学, 2005, (5): 371-374. |
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| 作者姓名： | 叶美娣 郑彩虹 |
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| 作者单位： | [1]浙江省湖州巾第一医院药剂科,浙江湖州313000 [2]浙江大学医学院附属妇产医院,浙江杭州310006 |
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| 摘 要： | 目的介绍近年来国内外对乳酸-羟基乙酸共聚物(PLGA)微球控释系统的突释的研究。方法分析有关文献资料,对产生突释的原因、影响突释的因素以及减少突释的方法进行详细介绍。结果和结论突释通常是不受欢迎的,随着对突释原因的深入了解,突释问题应能得到解决和控制。
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| 关 键 词： | 乳酸-羟基乙酸共聚物 微球 突释 制备参数 |
| 文章编号： | 1007-7693（2005）05-0371-04 |
| 收稿时间： | 2004-06-16 |
| 修稿时间： | 2004-06-16 |
The initial burst of PLGA microparticle systems |
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| YE Mei-di, ZHENG Cai-hong. The initial burst of PLGA microparticle systems[J]. Chinese Journal of Modern Applied Pharmacy, 2005, (5): 371-374. |
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| Authors: | YE Mei-di~ ZHENG Cai-hong~ |
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| Affiliation: | 1. Department of Pharmacy, The First Hospital of Zhejiang Huzhou,Huzhou 313000, China; 2. Affiliated Obstetric and Gynecology Hospital, Medical College, Zhefiang University, Hangzhou 310006, China |
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| Abstract: | OBJECTIVE To review previous research conducted to control the initial burst in poly(lactic-co-glycolic acid)(PLGA)microparticle systems.METHOD The cause of initial burst,the formulation parameters affecting initial release and approaches to reduce initial burst were all analyzed according to relevant literatures.RESULTS and CONCLUSION The burst release is usually not effective and welcome,it should be well controlled by studying the initial release problem thoroughly. |
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| Keywords: | PLGA microsphere initial burst formulation parameters |
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