Ketolide treatment of Haemophilus influenzae experimental pneumonia |
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| Authors: | Piper K E Rouse M S Steckelberg J M Wilson W R Patel R |
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| Affiliation: | Division of Infectious Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55902, USA. |
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| Abstract: | The MICs of HMR 3004 and HMR 3647 at which 90% of beta-lactamase-producing Haemophilus influenzae isolates were inhibited were 4 and 2 micrograms/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase-producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model. |
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