阿托伐他汀诱发乙型肝炎复发

1例47岁男性乙型肝炎患者，在接受经皮冠状动脉腔内成形术及支架植入术后，给予阿托伐他汀20mg，1次／d，氯吡格雷75mg，1次／d。约3个月后，患者因出现乏力、食欲下降、尿黄，ALT〉900U／L入住我院。实验室检查示ALT2549U／L，AST1621．7U／L，TBil 42．3μmol／L，HBVDNA 8．41×10^5copies／ml。停用阿托伐他汀，氯吡格雷等药物继续使用。患者予以保肝治疗。4周后，患者症状逐渐好转，其ALT、AST、TBil以及HBVDNA水平分别为73．9U／L，51．8U／L，22μmol／L及〈500copies／ml。

Recurrence of hepatitis B induced by atorvastatin

A 47-year-old man with hepatitis B was given atorvastatin 20 mg once daily and clopidogrel 75 mg once daily after undergoing percutaneous transluminal coronary angioplasty and stent implantation. About 3 months later, the patient was admitted to our hospital with fatigue, anorexia, and dark urine. Laboratory tests showed the following values： ALT 2 549 U/L, AST 1 621.7 U/L, TBil 42.3μmol/L, and HBV DNA 8.41× 10^5 copies/ml. Atorvastatin was discontinued, and clopidogrel was continued. He received liver-protective treatment. Four weeks later, his symptoms improved gradually, and his ALT, AST, TBil, and HBV DNA levels were 73.9 U/L, 51.8 U/L, 22μmol/L, and 〈500 copies/ml, respectively.