2型糖尿病患者经皮冠状动脉介入术后血清高敏C反应蛋白与心血管事件相关性

目的：探讨合并2型糖尿病的经皮冠状动脉介入治疗术(PCI)患者术后高敏 C 反应蛋白(hsCRP)水平及其与术后心血管事件发生的相关性。方法选择38例糖尿病 PCI 患者,及38例非糖尿病 PCI 患者,收集患者一般情况,PCI 手术前后 hsCRP 情况,手术后6个月内主要不良心脏事件(MACE)发生情况,分析术后72小时 hsCRP 水平与 MACE 的相关性。结果两组一般情况比较差异无统计学意义(P >0.05)。两组患者手术后 hsCRP 水平(15.94±3.49)μg/L,(11.67±3.28)μg/L]明显高于手术前(7.64±3.64)μg/L,(7.59±3.38)μg/L],差异有统计学意义(P <0.05),两组术前 hsCRP 水平差异无统计学意义(7.64±3.64)μg/L vs (7.59±3.38)μg/L,P >0.05],术后糖尿病 PCI 组 hsCRP 水平明显高于非糖尿病 PCI 组,差异有统计学意义(15.94±3.49)μg/L vs (11.67±3.28)μg/L,P <0.05]。术后6个月内糖尿病 PCI 组 MACE 发生率明显高于非糖尿病 PCI 组,差异有统计学意义31.6%(12/38)vs 13.2%(5/38),P <0.05],糖尿病 PCI 组 MACE 中以心绞痛及非 Q 波心肌梗死发生比例高(均为13.2%),非糖尿病 PCI 组中以心绞痛发生比例最高(7.9%)。合并2型糖尿病患者血 hsCRP 水平与 MACE 发生呈正相关(r =0.467,P <0.05)。结论合并糖尿病的患者 PCI 术后早期炎症反应更为严重,可促进血管再狭窄的出现和 MACE 的发生。

High sense C reactive protein and major adverse cardiac events in patients with type 2 diabetes following percutaneous coronary intervention

Objeetive To investigate the levels high sense C reactive protein（hsCRP） in patients with type 2 diabetes after percutaneous coronary intervention（PCI） and its correlation with postoperative cardiovascular events. Methods The study enrolled 38 PCI patients with diabetes mellitus,and 38 PCI patients without diabetic mellitus,the general data, hsCRP before and after PCI surgery, major adverse cardiac events （MACE） within six months after surgery of the patients were PCI collected, Spearman rank correlation analysis was used to illustrate the correlation between hsCRP level and MACE after for PCI 72 hours. Results The general conditions of two groups showed no significant difference（ P〉0.05）. The hsCRP levels of two groups after PCI（15.94±3.49） μg/L, （11.67±3.28） μg/ L were significantly higher than before PCI （7.64±3.64） μg/L, （7.59±3.38） μg/L（ P 〈0.05）. The postoperative hsCRP levels of diabetes PCI group （15.94±3.49） μg/L was significantly higher than that of non-diabetic PCI group （11.67± 3.28） μg/L（ P 〈0.05）. Within 6 months after PCI, the MACE of diabetic group 31.60//00 （12/38） was significantly higher than that of non-diabetic group 13.2% （5/38） （ P 〈0.05）. In diabetes PCI group, MACE mainly presented with angina and non-Q-wave myocardial infarction（both 13.2 ）, while in non diabetic group, MACE mainly with angina （7.9 %） . The blood hsCRP level of patients with type 2 diabetes mellitus was positively correlated with MACE（ r =0. 467, P %0.05）. Conclusion Early inflammatory response in patients with type 2 diabetes mellitus is more severe,which can promote the emergence of restenosis and MACE.