淋巴管内皮特异性标志物LYVE-1在肿瘤淋巴管生成中的研究

研究恶性肿瘤淋巴道转移发生、发展的机制在肿瘤的治疗中有着重要的价值。近来随着淋巴管内皮特异性标志物LYVE-1在肿瘤淋巴管生成中的广泛研究,有望在肿瘤淋巴结转移的研究中有重大突破,为临床抗肿瘤淋巴管生成的治疗提供新的理论依据。现对LYVE-1的结构和功能特点、表达的特异性以及在淋巴管生成中的作用进行综述。

Research into Lymphatic Endothelium Specific Marker LYVE-1 in Neoplasm Lymphangiogenesis

To study the mechanism about the occurrence and development of lymphatic metastasis has significant value in neoplasm metastasis.Recently,with the ongoing use of lyve-1,the lymphatic endothelium specific marker,it is hopeful to make great progress in studying the mechanism of tumor lymphangiogenesis and provide new theoretical foundations for clinical anti-tumor lymphangiogenesis therapy.The structural and functional feature,its expression specificity and applications in neoplasm metastasis studying is summarized in this article with regard to this.