TCR tuning of T cell subsets |
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Authors: | Jae-Ho Cho Jonathan Sprent |
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Affiliation: | 1. Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Korea;2. Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Korea |
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Abstract: | After selection in the thymus, the post-thymic T cell compartments comprise heterogenous subsets of naive and memory T cells that make continuous T cell receptor (TCR) contact with self-ligands bound to major histocompatibility complex (MHC) molecules. T cell recognition of self-MHC ligands elicits covert TCR signaling and is particularly important for controlling survival of naive T cells. Such tonic TCR signaling is tightly controlled and maintains the cells in a quiescent state to avoid autoimmunity. Here, we review how naive and memory T cells are differentially tuned and wired for TCR sensitivity to self and foreign ligands. |
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Keywords: | CD45 CD5 major histocompatibility complex molecules self-peptides T cell receptor TCR tuning |
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