| X线照射卵巢研究雌激素与免疫功能相关性的动物模型的建立 |
| |
| 引用本文： | 黄辉,司秋生,王新力,林云璐,王洪复.X线照射卵巢研究雌激素与免疫功能相关性的动物模型的建立[J].实验动物与比较医学,1993(2). |
| |
| 作者姓名： | 黄辉 司秋生 王新力 林云璐 王洪复 |
| |
| 作者单位： | 上海医科大学基础医学院免疫学教研室
(黄辉，司秋生，林云璐)，上海医科大学基础医学院放射医学研究所
(王新力)，上海医科大学基础医学院放射医学研究所(王洪复) |
| |
| 摘 要： | 采用X线局部照射大鼠的双侧卵巢,建立了雌激素缺乏的大鼠动物模型。实验发现X线照射卵巢三个月后大鼠血清雌二醇(E_2)含量明显降低,大鼠淋巴细胞的增殖及其产生白细胞介素2(IL—2)的能力升高。统计学分析表明,大鼠血清E_2含量与大鼠淋巴细胞产生IL—2的能力呈负相关。
|
| 关 键 词： | X线照射 雌二醇 白细胞介素2 卵巢 |
The Establishment of a Rat Model for the Studies on the Relationship between Estrogen and Immunity by X-ray Irridiated Ovaries |
| |
| Huang Hui.The Establishment of a Rat Model for the Studies on the Relationship between Estrogen and Immunity by X-ray Irridiated Ovaries[J].Laboratory Animal and Comparative Medicine,1993(2). |
| |
| Authors: | Huang Hui |
| |
| Abstract: | A rat model of lack of estradiol ( E2 ) was established by X-ray irradiation to ovaries. It was found that the reduction of E2 level in serum, increase of interleukin 2 ( IL-2 ) secretion and hyperplasia of lymphocytes. There was also a negative correlation between the level of E2 in serum and IL-2 production(r= -0.952, P<0.0005). The model would be a good subject for the associated research between estrogen and immune system. |
| |
| Keywords: | X-ray irradiation Estradiol Ovary Interleukin 2 |
|
| 点击此处可从《实验动物与比较医学》浏览原始摘要信息 |
| 点击此处可从《实验动物与比较医学》下载免费的PDF全文 |
