三种老年痴呆动物模型行为学比较

目的老年大鼠、基底前脑损伤大鼠及注射东莨菪碱大鼠常作为老年性痴呆的动物模型，本研究对这三种模型的行为表现进行比较研究。方法采用水迷宫及旷场分析法对这三种模型及青年对照和假手术对照进行了研究。结果老年大鼠、基底前脑损伤大鼠和注射东莨菪碱大鼠的学习记忆能力显著减弱，老年大鼠对新环境的紧张程度增强；基底前脑损伤大鼠和注射东莨菪碱大鼠的空间认知能力显著下降；注射东莨菪碱大鼠的兴奋性异常增强，（Ｐ＜００５）。结论基底前脑损伤动物的行为表现最符合老年痴呆患者的早期临床症状。

Behavioral Comparison Among Three Animal Models Mimicking Alzheimer's Disease

Objective The aged rats, basal forebrain-injured rats and the rats injected with scopolamine are ofter used as animal models of alzheimer''s disease. A behavioral comparison among three animal models were carried out in the study. Method Water maze and open field were applied in above three animal model groups, youth control group and sham operation control group. Results The ability of learning and memory in the aged rats, basal forebrain-injured rats and scopolamine-injected rats decreased significantly. The ability of spatial cognition in basal forebrain-injured rats and scopolamine-injected rats significantly declined. For the scopolamine-injected rats the excitability in new environment abnormally increased, (P<0.05). Conclusions The behavioral changes in basal forebrain-injured rats are more similar to the early clinical manifests of alzheimer''s disease than those in aged rats and scopolamine-injected rats.