| 聚乙二醇脂质体多柔比星二线治疗晚期铂类敏感型复发性卵巢癌的临床疗效观察 |
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| 引用本文： | 董文静,宫满成,萧剑军,江小梅,殷兆锋,李慧芬.聚乙二醇脂质体多柔比星二线治疗晚期铂类敏感型复发性卵巢癌的临床疗效观察[J].癌症进展,2019,17(9):1044-1046,1060. |
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| 作者姓名： | 董文静 宫满成 萧剑军 江小梅 殷兆锋 李慧芬 |
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| 作者单位： | 中山市人民医院化疗科,广东 中山,5284030;中山市人民医院泌尿外科,广东 中山,5284030 |
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| 摘 要： | 目的观察聚乙二醇脂质体多柔比星治疗晚期铂类敏感型复发性卵巢癌的临床疗效。方法将100例晚期铂类敏感型复发性卵巢癌患者分为观察组50例(采用聚乙二醇脂质体多柔比星+卡铂治疗)和对照组50例(采用吉西他滨+卡铂治疗)。比较两组患者的治疗效果和不良反应发生情况。结果两组患者的治疗有效率(RR)和疾病控制率(DCR)比较,差异均无统计学意义(P﹥0.05)。观察组患者中性粒细胞减少、血小板减少和恶心呕吐的发生率均低于对照组患者,手足综合征的发生率高于对照组患者,差异均有统计学意义(P﹤0.05)。结论聚乙二醇脂质体多柔比星可用于二线治疗晚期铂敏感型复发性卵巢癌,具有不良反应轻、患者依从性好的优点,值得临床推广应用。
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| 关 键 词： | 卵巢癌 聚乙二醇脂质体 多柔比星 不良反应 手足综合征 |
Clinical effects of pegylated liposomal doxorubicin as second-line treatment for advanced platinum-sensitive recurrent ovarian cancer |
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| DONG Wenjing,GONG Mancheng,XIAO Jianjun,JIANG Xiaomei,YIN Zhaofeng,LI Huifen.Clinical effects of pegylated liposomal doxorubicin as second-line treatment for advanced platinum-sensitive recurrent ovarian cancer[J].Oncology Progress,2019,17(9):1044-1046,1060. |
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| Authors: | DONG Wenjing GONG Mancheng XIAO Jianjun JIANG Xiaomei YIN Zhaofeng LI Huifen |
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| Institution: | (Department of Chemotherapy,the People’s Hospital of Zhongshan,Zhongshan 528403,Guangdong,China;Department of Urologic Surgery,the People’s Hospital of Zhongshan,Zhongshan 528403,Guangdong,China) |
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| Abstract: | DONG Wenjing;GONG Mancheng;XIAO Jianjun;JIANG Xiaomei;YIN Zhaofeng;LI Huifen(Department of Chemotherapy,the People’s Hospital of Zhongshan,Zhongshan 528403,Guangdong,China;Department of Urologic Surgery,the People’s Hospital of Zhongshan,Zhongshan 528403,Guangdong,China) |
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| Keywords: | ovarian cancer pegylated liposomal doxorubicin doxorubicin adverse reaction hand-foot syndrome |
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