| 黄花倒水莲降血脂活性成分研究 |
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| 引用本文： | 徐康平,黄伟,谭健兵,周应军,李福双,黄朝辉,刘保川,谭桂山.黄花倒水莲降血脂活性成分研究[J].中药材,2006,29(1):16-19. |
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| 作者姓名： | 徐康平 黄伟 谭健兵 周应军 李福双 黄朝辉 刘保川 谭桂山 |
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| 作者单位： | 1. 中南大学药学院药物化学系,湖南,长沙,410013
2. 中南大学药学院药物化学系,湖南,长沙,410013;中南大学湘雅医院药剂科,湖南,长沙,410008 |
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| 基金项目： | 湖南省科技厅科技攻关项目 |
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| 摘 要： | 从黄花倒水莲Polygala fallaxHem sl.根的降血脂有效部位中分离得到四个皂苷类化合物,分别鉴定为3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl presenegen in 28-O-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)--βD-fucopyransoyl ester(Ⅰ)、3-O--βD-glucopyranosyl-(1→2)--βD-glucopyranosyl presenegen in 28-O-β-D-xy-lopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-(3-O-acetyl)-β-D-fucopyranosyl ester(Ⅱ)、3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl presenegen in 28-O-β-D-xylopyranosyl-(1→4)--αL-rhamnopyranosyl-(1→2)-(4-O-acetyl)-β-D-fucopyranosyl ester(Ⅲ)和3-O-β-D-glucopyranosyl-(1→2)--βD-glucopyranosyl presenegen in 28-O-β-D-xylopyrano-syl-(1→4)-α-L-rhamnopyranosyl-(1→2)-(3,4-d iacetyl)--βD-fucopyranosyl ester(Ⅳ)。
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| 关 键 词： | 黄花倒水莲 皂苷 |
| 文章编号： | 1001-4454(2006)01-0016-04 |
| 收稿时间： | 2005-09-07 |
| 修稿时间： | 2005年9月7日 |
Study on the Antihyperlipidemia Effective Constituent of Polygala fallax Hemsl. |
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| XU Kang-ping,HUANG Wei,TAN Jian-bin,ZHOU Ying-jun,LI Fu-shuang,HUANG Zhao-hui,LIU Bao-chuan,TAN Gui-shan.Study on the Antihyperlipidemia Effective Constituent of Polygala fallax Hemsl.[J].Jorunal of Chinese Medicinal Materials,2006,29(1):16-19. |
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| Authors: | XU Kang-ping HUANG Wei TAN Jian-bin ZHOU Ying-jun LI Fu-shuang HUANG Zhao-hui LIU Bao-chuan TAN Gui-shan |
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| Institution: | 1. Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Central South University, Changsha 410013, China; 2. Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China |
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| Abstract: | OBJECTIVE: To study the antihyperlipidemia effective constituent of Polygala fallax Hemsl. METHOD: Column chromatographic techniques were employed for isolation and purification of chemical constituents of the plant and the structures were elucidated by IR, NMR and MS spectroscopy. RESULT: Four triterpenoid saponins were isolated and determined as 3-O-beta-D-glucopyranosyl-( 1--> 2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4 ) -alpha-L-rhamnopyranosyl-(1-->2 ) -beta-D-fucopyranosyl ester (I), 3-O-beta-D-glucopyranosyl-(1-->2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) -(3-O-acetyl)-beta-D-fucopyranosyl ester (II), 3-O-beta-D-glucopyranosyl-(1-->2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) -(4-O-acetyl) -beta-D-fucopyranosyl ester (II) and 3-O-beta-D-glucopyranosyl-(1--2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4 ) -alpha-L-rhamnopyranosyl-(1-->2 ) - (3,4-diacetyl) -beta-D-fucopyranosyl ester (IV). CONCLUSIONS: The effective constituents of Polygala fallax Hemsl. reduced blood lipid especially plasma TG markedly. The authors have studied the chemical constituents of effective constituent systematically for the first time. |
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| Keywords: | Polygala fallax Hemsl Triterpenoid saponins |
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