| 新型降脂药——依折麦布的研究进展 |
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| 引用本文： | 吴文静,柯元南,郑金刚. 新型降脂药——依折麦布的研究进展[J]. 心血管病学进展, 2009, 30(4): 558-561 |
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| 作者姓名： | 吴文静 柯元南 郑金刚 |
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| 作者单位： | 卫生部中日友好医院心内科,北京,100029 |
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| 摘 要： | 依折麦布为一种新型口服调血脂药物，它能选择性抑制肠道对胆固醇和相关植物甾醇的吸收。单独应用或与他汀类药物合用，均能降低具有冠心痛风险患者的血清胆固醇水平、现主要对其作用机制、药代动力学、药效学、临床疗效和安全性进行综述。
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| 关 键 词： | 高脂血症 药物疗法 依折麦布 调血脂药 |
Ezetimibe-A Novel Lipid Regulating Agent |
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| WU Wen-jing,KE Yuan-nan,ZHENG Jin-gang. Ezetimibe-A Novel Lipid Regulating Agent[J]. Advances in Cardiovascular Diseases, 2009, 30(4): 558-561 |
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| Authors: | WU Wen-jing KE Yuan-nan ZHENG Jin-gang |
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| Affiliation: | WU Wen-jing, KE Yuan-nan, ZHENG Jin-gang ( Department of Cardiology,Sino-Japan Friendship Hospital, Beijing 100029, China) |
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| Abstract: | Ezetimibe is a novel selective cholesterol absorptiun inhibitor. When given as monotherapy, or in combination with statins, ezetimihe can steadily reduce the plasma concentration of cholesterol. In this article, the mechanism, pharmaeokineties, pharmacodynamics, clinical efficacy, and safety are summarized. |
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| Keywords: | hyperlipidemia drug therapy ezetimibe lipid regulating agent |
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