自制碘油混合乳剂肝癌的联合化疗及栓塞的疗效分析

目的 :观察自制碘油混合乳剂经肝动脉栓塞术 (TAE)对中晚期肝癌的疗效和肝功能指标变化 ,并与常规TAE的疗效对比。方法 :79例中、晚肝癌分常规组和对照组经股动脉途径插管进行周期性治疗 ,灌注化疗物药 :AMD +5 FU +MMC +CDDP +羟基喜树碱 ,并进行碘油明胶海绵栓塞 ,常规组 :超液化碘油 +明胶海绵 ,对照组 :超液化碘油、阿霉素、5 氟脲嘧啶、无水酒精抽吸乳化 +明胶海绵 ;治疗前后检测血清ALT、AST水平 ,并随访生存期。结果 :治疗后 6个月、12个月、18个月生存率对照组 (10 0 %、76 .9%、6 4 .1% )较常规组 (82 .5 %、5 7.5 %、30 % )有明显增高 (P <0 .0 5 ) ,治疗后两组血清ALT、AST水平无显著差异 (P >0 .0 5 )。结论 :使用自制碘油混合乳剂经股动脉途径插管进行周期性栓塞治疗中晚期肝癌 ,可有效地提高患者的生存期。

Analysis of the effect of self-made lipiodol farrago in the embolism of hepatocarcinoma combined with chemical treatment

Objective:The purpose of this study was to observe the effect of self-made lipiodol farrago in operation of transcatheter artery embolizatoin (TAE) in patients with middle and late period hepatic tumors,and to observe the changing in parameters of hepatic function, and to compare the effect with usual treatment of TAE.Methods:79 cases of middle and late period hepatic tumors were divided into two groups: normal group and study group,all the patients accept the periodic treatment of TAE, drugs was given by means of femoral artery catheterization: AMD+5-FU+MMC+CDDP+HCPT, and arteries related to the tumor was embolismed with lipiodol gelfoam.study group:lipiodol, ADM,5-FU,mixed with alcohol free of water + gelfoam, normal group:lipiodol+ gelfoam;serum ALT and AST was examined before and after operation, all the patients were visited with in the survival time.Results:In 6 months,12 months, 18 months after operation, live rate of Study Group (100%, 76.9%, 64.1%) was higher than that in normal group (82.5%, 57 5%, 30%)(P<0.05),there was no difference in the level of serum AST and ALT between two groups (P>0.05).Conclusion:Treatment of TAE could effectively prolong the survival time of the patients.