Commentary on the speculations that Alzheimer's disease may begin in the nose and may be caused by Aluminosilicates

To be successful, the speculative scientific review must be provocative without being provoking. In the present instance, this goal has been achieved by a thoughtful attention to exposition: The author begins with scientifically indisputable facts from which he draws logical inferences; only then does he ask the reader's indulgence to follow his speculations. He concludes the review with a hypothesis that is especially attractive because it provides a novel explanation for the pathogenesis of Alzheimer's disease and because it is experimentally verifiable.