Studying outcomes of intensive care unit survivors: the role of the cohort study |
| |
| Authors: | David W Dowdy Dale M Needham Pedro A Mendez-Tellez Margaret S Herridge Peter J Pronovost |
| |
| Institution: | (1) School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA;(2) Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA;(3) Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA;(4) Department of Medicine, University of Toronto, Toronto, Ont., Canada;(5) Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA;(6) Department of Surgery, Johns Hopkins University, Baltimore, MD 21205, USA;(7) Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ont., Canada;(8) Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA |
| |
| Abstract: | Background As research focuses on long-term patient outcomes and the  real world effectiveness of intensive care unit (ICU) therapies, the cohort study is increasingly being used in critical care research.Methods Using examples of prior cohort studies in intensive care, we review the key elements of this research design and evaluate its advantages and limitations for critical care research. Furthermore, through a systematic search of the literature we summarize data from 70 prior published cohort studies of medium- and long-term outcomes in adult critical care medicine.Discussion This research demonstrates that the prospective cohort study is a powerful research design that has not been fully leveraged to assess relationships between exposures and long-term outcomes of ICU survivors.Conclusions We make recommendations for the design of future cohort studies to maximize the impact of this research in improving the long-term outcomes of critically ill patients.Electronic Supplementary Material Electronic supplementary material to this paper can be obtained by using the Springer Link server located at .An erratum to this article can be found at
This research was supported by National Institutes of Health (ALI SCCOR Grant # P050 HL 73994-01). D.M.N. is supported by Clinician-Scientist Awards from the Canadian Institutes of Health Research and the University of Toronto, and a Detweiler Fellowship from the Royal College of Physicians and Surgeons of Canada. |
| |
| Keywords: | Cohort studies Outcome assessment (health care) Risk factors Review literature Epidemiological methods Critical illness |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
