Detection of ischemic myocardium with a new hypoxic tissue targeting tracer99Tcm-HL91 |
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Authors: | Lü Jiagao Liu Gang Fang Ya Wu Hua |
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Institution: | (1) Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;(2) Department of Nuclear Medicine, Taihe Hospital, Yunyang Medical College, 442000 Shiyan, China;(3) Department of Preventive Medicine, Medical College, Xiamen University, 361005 Xiamen, China;(4) Department of Nuclear Medicine, Xiamen First Hospital, Fujian Medical University, 361003 Xiamen, China |
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Abstract: | Summary The imaging appearances of99Tcm-HL91, a new hypoxic imaging agent, in ischemic myocardium were studied and the value of99Tcm-HL91 in the evaluation of regional ischemic viable myocardium was explored. Acute myocardial ischemia models were made by
coronary artery legations in 18 rats and randomly divided into 2 groups:99Tcm-HL91 group and99Tcm-MIBI group. Evan blue infusion during ischemia and TTC staining after operation were used to delineate the area of ischemic
and viable myocardium. The isolated heart was sliced in the short axis and then autoradiography was performed. The electron
microscopic examination was also done for the myocardial samples.99Tcm-HL91 and99Tcm-MIBI uptake activities (counts/g) were measured in the area of ischemic myocardium (T) and normal myocardium (NT) separately.
The uptake ratios of99Tcm-HL91 and that of99Tcm-MIBI in ischemic myocardium were calculated as T/NT. It was found that the normal myocardium was blue and ischemic or infarct
myocardium was negative with Evans blue in all experiment rats. Both the normal and ischemic myocardium was in red color with
TTC staining. In the99Tcm-HL91 group the ischemic myocardium showed much higher uptake over normal myocardium, that was demonstrated both in the autoradiography
and quantitative analysis. The ischemic/normal activity ratios were 1.634±0.354. It was suggested that99Tcm-HL91 might accumulate in ischemic and viable myocardium, which is helpful in the evaluation of hypoxic but viable myocardium
and potentially used as a imaging agent to assess myocardial viability.
Lü Jiagao, male, born in 1965, Associate Professor |
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Keywords: | myocardial viability myocardial ischemia hypoxia 99Tcm-HL91 |
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