乳腺囊性增生病60临床病理分析

目的探讨乳腺囊性增生病与乳腺癌发生的关系。方法通过免疫组化SP法对乳腺囊性增生病进行bcl-2和PCNA标记。结果60例乳腺囊性增生病中，导管上皮不典型增生24例，bcl-2和PCNA的阳性表达分别为66．7％和54．2％；伴导管乳头状瘤者25例，bcl-2和PCNA的阳性表达为16．0％和20．0％；伴大汗腺化生者52例，bcl-2和PCNA的阳性表达为5．8％和7．7％；伴囊肿形成者53例，bcl-2和PCNA无阳性表达。结论乳腺囊性增生病伴导管上皮不典型增生者与乳腺癌的发生关系密切，而导管乳头状瘤、大汗腺化生、囊肿与癌的发生关系不大。

Clinicopathological analysis of 60 cases of mammary cystic hyperplasia

Objective To study the relationship between cystic hyperplasia and carcinoma of mammary. Methods Immunohistochemical staining was used to detect the expression of bcL-2 and PCNA in the cystic hyperplasis of mammary. Results Twenty four of 60 cases of mammary cystic hyperplasia showed atypical intraductal hyperplasia. The positive rates of bcl-2 and PCNA were 66.7% and 54. 2% respectively ;25 cases with ductal papilloma were 16.0% and 20.0% ;52 cases with apocHne metaplasia were 5.8% and 7.7% ;53 cases with cyst were negative. Conclusions The mammary cystic hyperpiasia with atypical intraductal hyperpiasia correlates closely with breast carcinoma,but papilloma,apocfine metaplasia,cyst correlate not closely.