惊恐障碍患者听觉信息自动处理的事件相关电位研究

目的探讨惊恐障碍患者听觉信息自动处理的特点。方法采用事件相关电位（ERP）成分～失匹配负波（MMN）,对15例惊恐障碍患者和15名正常对照的听觉信息自动处理过程进行客观评价。结果惊恐障碍患者的MMN波幅在60—210衄潜伏期窗内明显高于正常对照组（60—110ms：F1.28=11．413,P=0．02;110-160ms：F1．28=6．639,P=0．016;160—210ms：F1.28=5．758,P=0．023）,且表现出早期（60—160ms）左侧脑区优势效应。结论惊恐障碍患者存在对听觉信息变化的过度自动加工处理,为研究PD的发病机制提供了新的客观证据。

Automatic auditory information management in panic disorder patients: an event-related potentials study

OBJECTIVE: To investigate the characteristics of automatic auditory information management in sufferers of panic disorder (PD). METHOD: Mismatch negativity (MMN), as a component of event-related potentials, was recorded from 15 PD patients, 8 males and 7 females, aged 40 +/- 12, and 15 sex, and aged-matched controls. Repeated measures ANOVA was used on 4 representative electrodes: T3, T4, F3, and F4. RESULTS: Compared with the normal controls, the PD patients showed significant enlargement of MMN amplitude in 60 - 210 ms latency windows (60 - 110 ms: F(1, 28) = 11.413, P = 0.02; 110 - 160 ms: F(1, 28) = 6.639, P = 0.016; 160 - 210 ms: F(1, 28) = 5.758, P = 0.023), and exhibited early (60 - 160 ms) left encephalic region predominant effect. CONCLUSION: PD patients may deal excessive automatic processing of the auditory information changes which may assist in offering new objective evidence to understand the etiology of PD.