| TABLE OF CONTENTS |
| Preamble2 |
| 1. Introduction2 |
| 1.1. Key Questions3 |
| 2. Stroke Prevention in AF: Current Evidence and Guidelines3 |
| 3. Literature Review4 |
| 3.1. Background4 |
| 3.2. WATCHMAN4 |
| 3.3. Amplatzer Cardiac Plug7 |
| 3.4. LARIAT7 |
| 3.5. Other Percutaneous Devices and Surgical Approaches8 |
| 4. Care Team and Facilities8 |
| 4.1. Multidisciplinary Heart Team8 |
| 4.2. General Requirements9 |
| 4.3. Facilities9 |
| 5. Operator Training10 |
| 6. Protocols for Care10 |
| 7. Assessment of Patient Selection and Outcomes10 |
| Appendix 1. Relevant Author Relationships With Industry and Other Entities–ACC/HRS/SCAI Left Atrial Appendage Occlusion Device Societal Overview14 |
| Appendix 2. Reviewer Relationships With Industry And Other Entities–2015 ACC/HRS/SCAI Left Atrial Appendage Occlusion Device Societal Overview15 |
