应激对戒断不同时间海洛因依赖者冲动性选择的影响

目的：药物依赖是一种以反复发作的强迫性觅药和摄药行为为主要特征的慢性复发性脑病。临床发现海洛因依赖者停药后数月乃至数年,虽然戒断症状早已消失,但对曾经用药所引起的欣快感或奖赏效应的顽固记忆却持续存在,当脱毒者再次受到应激事件时,表现为自我控制能力下降、冲动行为增加,使脱毒者在康复期出现极高的复吸率。应激能引起药物依赖者的渴求增加而导致复吸已经被多数研究者证实,但是应激对戒断不同时间的海洛因依赖者冲动性选择的影响尚无相关的研究。

EFFECTS OF STRESS ON DECISION-MAKING IN HEROIN ADDICTS AT DIFFERENT ABSTINENT TIME

Objective：The typical clinical characteristics of drug dependence are compulsive drug seeking and drug taking. Evidences from clinical studies suggest that the craving for addictive substance of drug addicts keeps out of self- control even after long -term withdrawal, while the physiological symptoms might have disappeared for months or years. They perform with little or inadequate forethought and then continue drug taking. It has been proved that stress can induce drug craving. But there are rare studies on effects of stress on impulsive choice of heroin addicts at different abstinent time. The purpose of the present study was to investigate the effects of stress on decision - making in heroin addicts at different abstinent time.