| 多不饱和脂肪酸衍生物对急性肺损伤的保护作用研究进展 |
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| 引用本文： | 孙威,武庆平. 多不饱和脂肪酸衍生物对急性肺损伤的保护作用研究进展[J]. 国外医学:麻醉学与复苏分册, 2013, 0(11): 1038-1042 |
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| 作者姓名： | 孙威 武庆平 |
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| 作者单位： | [1]武汉市中心医院麻醉科,430014 [2]华中科技大学同济医学院附属协和医院麻醉科,430014 |
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| 基金项目： | 国家自然基金（N081070060） |
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| 摘 要： | 背景急性肺损伤（acute lung injury，ALI）是目前严重威胁人类健康的疾病之一。有大量研究表明：源自多不饱和脂肪酸（polyunsaturated fatty acids，PUFA）的一些特殊的促炎症消退介质（specialized pro-resolving mediators，SPM）对ALI具有一定的保护作用。目的分析总结SPM对ALI的保护作用和机制。内容此文描述SPM的分子生物学特征、炎症与ALI的关系，SPM的抗炎和促进炎症消退的保护作用及机制3个方面。趋向SPM对ALI具有一定的保护作用，这对于临床上治疗ALI提供了一种新的思路和方法。
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| 关 键 词： | 急性肺损伤 多不饱和脂肪酸 炎症 |
The research progress of the protective effect of polyunsaturated fatty acids derived lipid mediators on acute lung injury |
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| SUN Wei＊,WU Qing-ping. The research progress of the protective effect of polyunsaturated fatty acids derived lipid mediators on acute lung injury[J]. Foreign Medical Sciences(Anesthesilolgy and Resuscitation), 2013, 0(11): 1038-1042 |
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| Authors: | SUN Wei＊ WU Qing-ping |
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| Affiliation: | . ＊Department of Anesthesiology, Wuhan Central Hospital, Wuhan 430014, China |
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| Abstract: | Background Acute lung injury （ALI） is one of the devastating diseases which threat human health. Series of studies have demonstrated the protective effect of Specialized Pro-resolving Mediators （SPM） derived from polyunsaturated fatty acids （PUFA） on ALL Objective Analyzing and summarizing the protective effect of SPM on ALI and its mechanism. Content This review exposits the molecular biology characteristics of SPM, the relationship between inflammation and acute lung injury and the protective effect and mechanism of anti-inflammation and pro-inflammation resolution of SPM on ALI. Trend With the protective effect on ALI, SPM provides us a new way on the clinical treatment of ALL |
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| Keywords: | Acute lung injury Polyunsaturated fatty acids Inflammation |
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