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引用本文:钱德云,徐自祥,陈建中,王维琦,赵泓霖.??????????????????????????δ??????1???????о?[J].中国实用口腔科杂志,2012,5(8):473-475.
作者姓名:钱德云  徐自祥  陈建中  王维琦  赵泓霖
作者单位:1.????????????????????????? ??? 655600??2.????????????????????? 650031??3.??????????????????????? 650000
基金项目:云南省教育厅基金项目(2011Y198)
摘    要:目的研究发育期SD大鼠髁状突颈部骨折对下颌髁状突软骨细胞中上游刺激因子1(USF1)表达的影响。方法本研究于2011年7—9月在昆明医科大学口腔医学院研究所完成。选择4周龄雄性SD大鼠12只,其中6只大鼠用于制作下颌单侧髁状突颈部骨折动物模型,6只大鼠为对照。分别在术后1、3、5周时处死大鼠,取出骨折侧、骨折对侧以及空白对照的髁状突软骨。采用免疫组织化学方法检测髁状突软骨细胞中USF1表达情况。结果术后1周,骨折对侧空白对照组与骨折侧的USF1表达有显著性差异(P<0.01);术后3周,空白对照组与骨折侧USF1表达有显著性差异(P<0.01)。骨折侧术后3周、5周与术后1周USF1表达有显著性差异(P<0.01)。结论单侧髁状突颈部骨折引起应力变化,使患侧髁状突软骨细胞中USF1表达异常,进而影响髁状突的生长发育。

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Effect of unilateral condylar neck fracture on USF1 expression of the chondrocyte in growing rat
QIAN De-yun,XU Zi-xiang,CHEN Jian-zhong,WANG Wei-qi,ZHAO Hong-lin.Effect of unilateral condylar neck fracture on USF1 expression of the chondrocyte in growing rat[J].chinese Journal of Practical Stomatology,2012,5(8):473-475.
Authors:QIAN De-yun  XU Zi-xiang  CHEN Jian-zhong  WANG Wei-qi  ZHAO Hong-lin
Institution:. Stomatology departmant of Luliang Peo- ple s Hospital, Luliang 655600, China
Abstract:Objective To investigate the effect of unilateral condylar neck fracture on USF1 expression of the chondrocyte in growing rats. Methods Twelve 4-week-old rats were randomly divided into two parts: half were operated to cause condylar fracture, the other part as control. The rats were killed at 1,3 and 5 weeks after surgery, and the condylar cartilage was obtained from the operating side and non-operating side of experimental group and control group. Immunohistochemical staining was used to qualitively examine USF1 expression. Results There was significant difference between non-operating side, control group and operating side at 1 week after surgery. There was significant difference between operating side and control group at 3 weeks after surgery. There was significant difference between 3 and 5 weeks and 1 week after surgery on operating side. Conclusion The unbalanced stress caused by unilateral condylar neck fracture change USF expression affect the development and growth of condyle.
Keywords:fracture  condylar cartilage  USF1  rat  ehondroeyte
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