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| 胰岛素样生长因子-Ⅰ在人股动脉粥样斑块中的表达 | |
| 引用本文： | 张大伟,张立燕,金星.胰岛素样生长因子-Ⅰ在人股动脉粥样斑块中的表达[J].中国中西医结合外科杂志,2007,13(5):444-446. |
| 作者姓名： | 张大伟 张立燕 金星 |
| 作者单位： | 1. 山东中医药大学附属医院周围血管病科,济南,250011 2. 山东济南槐荫区医院外科 3. 山东省立医院血管外科 |
| 摘 要： | 目的:探讨胰岛素样生长因子-Ⅰ在动脉粥样硬化斑块中的表达及分布特点。方法:应用免疫组织化学技术测定31例人体股动脉粥样斑块中胰岛素样生长因子-Ⅰ的表达。结果:闭塞性动脉硬化症患者股动脉动脉粥样斑块中胰岛素样生长因子-Ⅰ呈强阳性表达,且主要分布在平滑肌细胞密集的部位。而正常人动脉壁中胰岛素样生长因子仅在中膜有微量表达。结论:说明胰岛素样生长因子-Ⅰ在动脉粥样斑块中的表达增高与AS及ASO的发生密切相关。 |
| 关 键 词： | 胰岛素样生长因子-Ⅰ 闭塞性动脉硬化症 动脉粥样硬化 免疫组织化学 |
| 文章编号： | 1007-6948（2007）05-0444-03 |
| 修稿时间： | 2006-11-02 |
Expression and Distribution of Insulin-like Growth Factor-I in Arteriosclerosis Plaque of Human Femoral Artery |
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| Zhang Dawei,Zhang Liyan,Jin Xing.Expression and Distribution of Insulin-like Growth Factor-I in Arteriosclerosis Plaque of Human Femoral Artery[J].Chinese Journal of Surgery of Integrated Traditional and Western Medicine,2007,13(5):444-446. | |
| Authors: | Zhang Dawei Zhang Liyan Jin Xing |
| Abstract: | Objective To investigate the expression and distribution of insulin like growth fatctor-I (IGF-I) in arteriosclerosis(AS) plaque of arteriosclerosis obliterans(ASO) cases Methods The protein level and area of IGF-1 in AS plaque and normal human artery were studied by means of immunohistochemistry. Results The expression of IGF-I has a high level in AS plaque and mainly distributed in the area where there were plenty of vascular smooth muscle cells, in contrast the expression of IGF-I was very low in normal arterial walls. Conclusion The higher level expression of IGF-I was related to the pathogenesis of AS and ASO. |
| Keywords: | insulin like growth factor-I arteriosclerosis obliterans arteriosclerosis immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |