17q21-qter trisomy is an indicator of poor prognosis in acute myelogenous leukemia |
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Authors: | Morerio C Russo I Rosanda C Rapella A Leszl A Basso G Maserati E Pasquali F Panarello C |
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Affiliation: | Divisione di Ematologia ed Oncologia Pediatrica, Istituto Giannina Gaslini, L. go G. Gaslini 5, 16147, Genova, Italy. |
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Abstract: | A reciprocal translocation (9;11) is often found in acute myeloid leukemia (AML), mostly of the M5a type. We report a case of a child with AML, in whom t(9;11) was observed at diagnosis as the sole structural abnormality, together with trisomies 19 and 21. The diagnosis was AML evolving from a myelodysplastic syndrome (MDS), and the blast morphology was undifferentiated. Chemotherapy failed to induce morphological remission and the patient's condition soon worsened. A subclone appeared and expanded during the course of the disease, with an additional unbalanced translocation (1;17) leading to trisomy of the long arm of chromosome 17 (17q). The data available from the literature on acquired anomalies involving 17q and our observation led us to postulate a specific link between the gain of 17q and complete chemoresistance. |
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