| 肿瘤多药耐药机制及逆转药物的研究进展 |
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| 引用本文： | 吴亚琼,方伟蓉,李运曼. 肿瘤多药耐药机制及逆转药物的研究进展[J]. 药学与临床研究, 2016, 24(1): 43-47 |
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| 作者姓名： | 吴亚琼 方伟蓉 李运曼 |
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| 作者单位： | 中国药科大学基础医学与临床药学学院天然药物活性组分与药效国家重点实验室,南京,210009 |
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| 摘 要： | 导致肿瘤多药耐药的机制很复杂，主要涉及有：ATP结合盒型转运蛋白超家族、DNA甲基化、细胞凋亡、拓扑异构酶Ⅱ、谷胱甘肽解毒系统及相关多药耐药信号通路等，这些机制单独或共同存在而导致耐药。逆转肿瘤多药耐药的方法主要有：化疗增敏剂、中药逆转剂和基因工程技术逆转耐药等。本文就肿瘤多药耐药机制的研究进展及逆转耐药的方法作一综述。
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| 关 键 词： | 肿瘤 多药耐药 耐药逆转剂 |
| 收稿时间： | 2015-10-12 |
| 修稿时间： | 2016-01-28 |
Mechanisms and Reversing Drugs of Cancer Multidrug Resistance |
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| WU Ya-qiong,FANG Wei-rong and LI Yun-man. Mechanisms and Reversing Drugs of Cancer Multidrug Resistance[J]. Pharmacertical and Clinical Research, 2016, 24(1): 43-47 |
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| Authors: | WU Ya-qiong FANG Wei-rong LI Yun-man |
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| Affiliation: | State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China,State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China |
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| Abstract: | The mechanism of multidrug resistance typically derives from several complex mechanisms involving ATP-binding cassette transporters, DNA methylation, apoptosis, topoisomerase II and/or glutathione. There are several novel approches reversing cancer multidrug resistance including Chemosensitizers, trandi-tional Chinese medicine reversal agents and genetic engineering technology. Herein we reviewed major mechanisms resulting in multidrug resistance and several drugs reversing multidrug resistance. |
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| Keywords: | Tumor Multidrug resistance Reversal agents |
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