芬太尼透皮贴治疗食管癌放疗疼痛的疗效观察

目的观察芬太尼透皮贴治疗食管癌放疗引起的食道黏膜炎所致疼痛的疗效。方法将2012年1-6月我科收治的30例经病理学诊断为食管癌并在放疗过程中出现急性食道黏膜炎所致中、重度疼痛的患者,分为对照组（15例）和研究组（15例）,研究组在放疗基础上加用芬太尼透皮贴,对照组仅行放疗,观察两组患者治疗过程中及治疗结束后的疼痛情况、生活质量评分和不良反应。结果研究组疼痛缓解有效率为86.67%,对照组为20.00%;研究组不良反应发生率低,且均能耐受。结论芬太尼透皮贴用于食管癌放疗相关性食道黏膜炎所致中、重度疼痛,镇痛作用强,不良反应轻,利于放疗顺利完成。

Curative effect of transdermal fentanyl on pain in patient with esophageal cancer after radiotherapy

Objective To study the curative effect of transdermal fentanyl in patients with esophageal cancer who had pain due to radiotherapy-induced acute esophageal mucositis.Methods Thirty patients with pathology-confirmed esophageal cancer,who had moderate and severe pain due to radiotherapy-induced acute esophageal mucositis,were divided into treatment group and control group（15 each group）.The patients in treatment group received chemotherapy plus transdermal fentanyl therapy and those in control group received only chemotherapy.Their pain,quality of life,and adverse reactions were observed during and after treatment.Results The effective pain relief rate was 86.67% in treatment group and 20.00% in control group.The incidence of adverse reactions was lower in treatment group than control group.The patients in treatment group could tolerate the treatment.Conclusion Transdermal fentanyl is effective on radiotherapy-induced moderate and severe pain due to esophageal mucositis in patients with esophageal cancer with few adverse reactions and a strong analgesic effect,and is thus beneficial to the successful radiotherapy.