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Integrated exposure assessment of sewage workers to genotoxicants: an urinary biomarker approach and oxidative stress evaluation |
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| Authors: | Hamzeh Al Zabadi Luc Ferrari Irène Sari-Minodier Marie-Aude Kerautret Aziz Tiberguent Christophe Paris Denis Zmirou-Navier |
| Institution: | 1.An-Najah National University, School of Medicine-Public Health Department,Nablus;2.INSERM U954, School of Medicine,54505 Vand?uvre-lès-Nancy,France;3.Nancy University Faculty of Pharmacy,Nancy,France;4.Nancy University School of Medicine,France;5.Aix-Marseille University School of Medicine,Marseille,France;6.Paris City Hygiene laboratory,Paris,France;7.Occupational medicine service of the City of Paris,France;8.EHESP School of Public Health-IRSET,Rennes,France |
| Abstract: | BackgroundSewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative stress. We aimed to explore integrated urinary biomarkers, assessing the overall urine genotoxicity by in vitro comet and micronucleus assays and measuring urinary 8-oxo-2'-deoxyguanosine. |
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