NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol |
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| Authors: | Lisa M Askie Peter Brocklehurst Brian A Darlow Neil Finer Barbara Schmidt William Tarnow-Mordi and The NeOProM Collaborative Group |
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| Institution: | (1) NHMRC Clinical Trials Centre, University of Sydney, (Parramatta Road), (2050) Camperdown, Australia;(2) National Perinatal Epidemiology Unit (NPEU), University of Oxford, (Old Road Campus), (OX3 7LF) Oxford, UK;(3) Christchurch School of Medicine, University of Otago, (Riccarton Avenue), (8140) Christchurch, New Zealand;(4) Division of Neonatology, University of California San Diego (UCSD) Medical Center, (West Arbor Drive), (92103) San Diego, USA;(5) Children’s Hospital of Philadelphia, University of Pennsylvania, (Spruce Street), (19104) Philadelphia, USA;(6) Neonatal Trials Group, McMaster University, (Concession Street), (L8V 1C3) Hamilton, Canada;(7) Westmead Hospital, University of Sydney, (Cnr Hawkesbury and Darcy Roads), (2145) Westmead, Australia;(8) Children’s Hospital at Westmead, University of Sydney, (Cnr Hawkesbury Road and Hainsworth Street), (2145) Westmead, Australia |
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| Abstract: | Background The appropriate level of oxygenation for extremely preterm neonates (<28 weeks' gestation) to maximise the greatest chance
of survival, without incurring significant morbidity, remains unknown. Infants exposed to lower levels of oxygen (targeting
oxygen saturations of <90%) in the first weeks of life are at increased risk of death, cerebral palsy, patent ductus arteriosus,
pulmonary vascular resistance and apnoea, whilst those maintained in higher levels of oxygen (targeting oxygen saturations
of >90%) have been reported to have greater rates of morbidity including retinopathy of prematurity and chronic lung disease.
In order to answer this clinical dilemma reliably, large scale trial evidence is needed. |
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