Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus |
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| Authors: | Sudeshna Dasgupta F Yesim Demirci Amy S Dressen Amy H Kao Elisa Y Rhew Rosalind Ramsey-Goldman Susan Manzi Candace M Kammerer M Ilyas Kamboh |
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| Affiliation: | (1) Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA;(2) Division of Rheumatology and Clinical Immunology, Lupus Center of Excellence, Pittsburgh, PA, USA;(3) Division of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA;(4) West Penn Allegheny, Pittsburgh, PA, USA |
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| Abstract: | Background Low serum paraoxonase (PON) activity is associated with the risk of coronary artery disease, diabetes and systemic lupus erythematosus (SLE). Our prior studies have shown that the PON1/rs662 (p.Gln192Arg), PON1/rs854560 (p.Leu55Met), PON3/rs17884563 and PON3/rs740264 SNPs (single nucleotide polymorphisms) significantly affect serum PON activity. Since PON1, PON2 and PON3 share high degree of structural and functional properties, in this study, we examined the role of PON2 genetic variation on serum PON activity, risk of SLE and SLE-related clinical manifestations in a Caucasian case-control sample. |
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