氟比洛芬酯复合小剂量芬太尼用于胃肠外科患者术后静脉自控镇痛的临床观察

目的:评估氟比洛芬酯复合小剂量芬太尼在胃肠手术后患者静脉自控镇痛(patient controlled intravenous analgesia,PCIA)中的效果和安全性.方法:90例择期行胃肠外科手术患者,均采用静脉吸入复合麻醉,术后行PCIA,并根据不同的用药方法随机分为A、B、C 3组,每组30例.A组:芬太尼1.0mg+生理盐水至100 mL;B组:氟比洛芬酯100 mg+芬太尼1.0 mg+生理盐水至100 mL;C组:氟比洛芬酯1 00 mg+芬太尼0.5 mg+生理盐水至1 00 mL. PCIA工作方式采用持续背景剂量(2 mL/h)配合单次按压剂量(0.5 mL/次),锁定时间为1 5 min.分别采用视觉模拟(visual analogue scales,VAS)评分评估24 h内的镇痛效果,记录24 h内PICA按压次数,恶心、呕吐等不良反应的发生情况.结果:患者均获得较好的镇痛效果.3组VAS评分及按压次数差异无统计学意义(P>0.05);随访观察A组和B组恶心、呕吐、嗜睡等不良反应发生率明显高于C组(P<0.05);镇痛期间A组2例发生呼吸抑制,3组均未发生异常出血等并发症.结论:相对于单独应用芬太尼,氟比洛芬酯复合小剂量芬太尼应用于胃肠外科术后静脉镇痛效果相同,但能够有效减少芬太尼的用量,降低不良反应的发生率.

Clinical observation of postoperative intravenous analgesia with flurbiprofen axetil injection combined with low-dose fentanyl in gastrointestinal surgery

Objective:To assess analgesic efficacy and safety of postoperative analgesia with flurbiprofen axetil combined with low-dose fentanyl.Methods:Ninty patients were randomly divided into A,B,C groups and with 30 cases in each group.For postoperative PCIA,the patients in Group A received Fentanyl(1.0 mg) + 0.9% Nacl solution to 100 mL,Group B,flurbiprofen(100 mg) + Fentanyl(1.0 mg)+ 0.9% Nacl solution to 100 mL,and Group C,flurbiprofen(100 mg)+ Fentany(l0.5 mg)+ 0.9% Nacl solution to 100 mL.All the anesthetic a...