乳腺癌肝转移患者预后的多因素分析

目的:分析影响乳腺癌肝转移患者的预后因素。方法:1996年1月~2003年12月,本院收治114例乳腺癌肝转移住院患者。利用Cox模型分析患者的预后因素。结果:乳腺癌肝转移患者的一线、二线、三线和四线化疗的疗效依此下降,分别为31.9%(22/69)、27.8%(10/36)、16.7%(3/18)和0%(0/10)。单因素分析提示无肝功能损害和手术后无疾病复发间歇期长者预后好。Cox多因素分析模型分析结果提示有无肝功能损害是影响生存率的独立预后因素。结论:晚期乳腺癌化疗疗效随着使用方案次数的增多而降低。有无肝功能损害是影响乳腺癌肝转移患者的独立预后因素。

Multivariate analyses of prognostic factors for breast cancer patients with liver involvement

Purpose:To investigate the prognostic factors for breast cancer patients with liver involvement.Methods:114 breast cancer patients with liver metastases,who were hospitalized in Fudan University Cancer Hospital between January,1996 and December,2003,were included in this study.Their survival data were analyzed.Results:The response rates with first-,second-,third-,fourth-line chemotherapy were 31.9%,27.8%,16.7% and 0%,respectively.Univariate analyses indicated that patients with impaired liver function and patients with a short interval between surgery and the first recurrence or metastasis had a poor prognosis.Multivariate analyses suggested that the presence of liver function impairment was an independent prognostic factor for overall survival.Conclusions:The response rates of chemotherapy drop with number of lines of chemotherapy.Breast cancer patients with liver involvement and impaired liver function have a poor prognosis.