| 糖皮质激素冲击治疗Ⅲ期结核性脑膜炎疗效观察 |
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| 引用本文： | 王焱烽,陈冰,姚茂元.糖皮质激素冲击治疗Ⅲ期结核性脑膜炎疗效观察[J].临床医学,2009,29(12):21-22. |
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| 作者姓名： | 王焱烽 陈冰 姚茂元 |
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| 作者单位： | 南京医科大学附属淮安市第一人民医院神经内二科,江苏淮安,223300 |
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| 摘 要： | 目的探讨糖皮质激素冲击治疗晚期结核性脑膜炎的有效性和安全性。方法将50例Ⅲ期结核性脑膜炎患者随机分为两组，在抗痨治疗的基础上，治疗组（25例）给予甲基强的松龙500mg/d静脉滴注冲击治疗5d后，迅速减至80mg/d后逐渐减量，对照组（25例）z给予地塞米松15mg/d治疗，症状明显好转后减量，两组激素使用疗程均最多10周。结果治疗组意识障碍恢复时间、体温恢复时间等均优于对照组（P〈0．05）；疗程12周时的治愈率、好转率及后遗症比较，治疗组均优于对照组（P〈0．05），不良反应间差异无统计学意义。结论大剂量甲基强的松龙冲击治疗Ⅲ期结核性脑膜炎疗效显著且不良反应无明显增加。
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| 关 键 词： | 糖皮质激素 冲击治疗 Ⅲ期结核性脑膜炎 |
Curative effects observataion of high-dose methylprednisolone on treating advanced tuberculous meningitis |
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| WANG Yanfeng,CHEN Bing,YAO Maoyuan.Curative effects observataion of high-dose methylprednisolone on treating advanced tuberculous meningitis[J].Clinical Medicine,2009,29(12):21-22. |
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| Authors: | WANG Yanfeng CHEN Bing YAO Maoyuan |
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| Institution: | WANG Yanfeng,CHEN Bing,YAO Maoyuan.The Second Department of Neurology,the First People's Hospital of Huaian,Nanjing Medical University,Huaian 223300,China |
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| Abstract: | Objective To observe the therapeutic efficacy of high-dose methypredhnisolone on treating advanced tuberculous meningitis.Methods Fifty patients with advanced tuberculous meningitis were randomly divided into two groups,baseing initiate antiphthisic treatment,treatment group was administered high-dose methyprednisolone(500 mg/d)by intravenous injections for five days,then was given methyprednisolone with 80 mg/d,and was maintained.Control group was treated with dexamethasone(15 mg/d),then was maintained aft... |
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| Keywords: | High-dose methylprednisolone Shock treatment Advanced tuberculous |
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