Association between Urine Albumin-to-Creatinine Ratio within the Normal Range and Incident Hypertension in Men and Women |
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| Authors: | Dhananjay Yadav Dae Ryong Kang Sang-Baek Koh Jang-Young Kim Song Vogue Ahn |
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| Affiliation: | 1Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.;2Department of Humanities and Social Medicine, Ajou University School of Medicine, Suwon, Korea.;3Institute of Genomic Cohort, Yonsei University, Wonju, Korea.;4Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. |
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| Abstract: | PurposeThere have been few studies on gender difference in the impact of a urine albumin-to-creatinine ratio (UACR) within the normal range on the risk of hypertension. We evaluated whether the association between the UACR below the microalbuminuria range and the incident risk of hypertension is different between men and women.ResultsDuring an average of 2.6 years of follow-up, 57 men (12.9%) and 66 women (9.0%) developed hypertension. In multivariable-adjusted models, the odds ratio for new-onset hypertension comparing the highest and lowest tertiles of UACR was 1.83 [95% confidence interval (CI) 0.85–3.94] in men and 2.69 (95% CI 1.27–5.73) in women. In stratified analyses by menopausal status, higher tertiles of UACR were associated with an increased risk of incident hypertension in postmenopausal women.ConclusionHigher normal UACR levels were associated with an increased risk of incident hypertension in women. The UACR could have a clinical role in predicting the development of hypertension. |
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| Keywords: | Albuminuria hypertension prospective study |
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