Electromotor feeding responses of primate ileum and colon |
| |
Authors: | Lelan F Sillin William J Schulte James H Woods Verne E Cowles Robert E Condon Paul Bass |
| |
Institution: | 1. Milwaukee, Wisconsin, USA;2. Madison, Wisconsin, USA |
| |
Abstract: | Serosal bipolar electrodes to record spike discharges and strain gauge force transducers to record circular muscle contractions were placed in pairs on the terminal ileum, cecum, right colon at the ileocecal valve, ascending colon, and proximal transverse colon of sixteen primates. After an overnight fast, electromotor responses to continued fasting or to ingestion of a meal (randomized order) were recorded in awake animals.Feeding led to increased spike discharges and increased frequency of muscle contractions at all sites. The onset of these responses usually was within 6 minutes after feeding; the responses increased progressively during 30 to 45 minutes and then remained more or less at a constant plateau of increased activity. Atropine completely blocked the postcibal responses of ileum and proximal colon for up to 30 minutes.Transit time data of labeled meals excluded direct stimulation by a food bolus as the mechanism of the observed postcibal colonic response. The pattern of response was consistent with humoral mediation. |
| |
Keywords: | Reprint requests should be addressed to Robert E Condon MD Surgical Service (112) VA Center Wood Wisconsin 53193 |
本文献已被 ScienceDirect 等数据库收录! |
|