Neural control of the canine pylorus |
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Authors: | Gordon L. Telford Sidney S. Mir G.Robert Mason Herbert S. Ormsbee |
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Affiliation: | Baltimore, Maryland, USA |
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Abstract: | After atropine administration the anesthetized dog exhibits significant spontaneous pyloric contractile activity and an inhibition-relaxation response upon electrical vagal stimulation. This inhibition-relaxation response was completely blocked by tetrodotoxin administration and by transection of the intraabdominal vagal nerves. In addition, tetrodotoxin administration caused a dramatic increase in spontaneous pyloric motor activity. The histaminergic receptor antagonists diphenhydramine and cimetidine did not block the inhibition-relaxation response. The octapeptide of cholecystokinin (CCK-OP) caused a dose-dependent increase in antral and pyloric motor activity which was significantly decreased by atropine administration. Therefore, histamine and CCK do not appear to play a significant role in the vagally mediated inhibition-relaxation response of the canine pylorus or in the atropine-resistant spontaneous pylorip motor activity. |
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Keywords: | Reprint requests should be addressed to H. S. Ormsbee III PhD Box 85 University of Maryland Hospital 22 South Greene Street Baltimore Maryland 21201. |
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