Responsiveness and calibration of the general well-being adjustment scale in patients with hypertension |
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Authors: | Dennis A. Revicki Harris Allen Kathleen Bungay Gordon H. Williams Milton C. Weinstein |
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Affiliation: | a Batelle Medical Technology Assessment and Policy Research Center, Arlington, VA, U.S.A. b Institute for the Improvement of Medical Care and Health, New England Medical Center, USA c Division of Endocrinology and Hypertension, Department of Medicine, Brigham and Womens Hospital and Harvard Medical School, U.S.A. d Department of Health Policy and Management, Harvard School of Public Health, U.S.A. |
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Abstract: | We examined the discriminant ability and responsiveness of the General Well-Being Adjustment Scale in patients enrolled in a randomized clinical trial of antihypertensive therapy. We also tried to translate the effects of physical symptoms on general well-being. This secondary analysis used demographic, clinical, physical symptom, and general well-being data for 545 white, male hypertensive patients. General well-being was measured by the General Well-Being Adjustment Scale (GWB) collected on 2 occasions over 8 weeks of treatment. Patients with any one of 14 physical symptoms or problems, compared to those without symptoms, had lower GWB scores (p < 0.003 to p < 0.0001). Decreases of 2.83–8.76 points in GWB scores were observed in patients developing physical symptoms over the 8 week study period (p < 0.05 to p < 0.0001). These effects were demonstrated in patients developing cold sensitivity, sexual problems, chest pain, shortness of breath, loss of taste, nausea, hot or cold spells, numbness and tingling, dry mouth, blurred vision, and dizziness. We conclude that the GWB is responsive to clinically meaningful changes in symptoms and may provide a more complete evaluation of the effects of medical treatment. The GWB is a valid and responsive measure of health status outcomes in the evaluation of antihypertensive treatment. |
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Keywords: | Author Keywords: Health status assessment Responsiveness Clinical symptoms Hypertension Calibration General Well-Being Adjustment Scale |
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